منابع مشابه
IAP family proteins--suppressors of apoptosis.
Apoptosis is a physiological cell suicide program that is critical for the development and maintenance of healthy tissues. Dysregulation of cell death pathways occur in cancer, autoimmune and immunodeficiency diseases, reperfusion injury after ischemic episodes, and in neurodegenerative disorders. Thus, proteins involved in apoptosis regulation are of intense biological interest and many are at...
متن کاملIAP-IAP Complexes Required for Apoptosis Resistance of C. trachomatis–Infected Cells
Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood. Here we investigated the molecular mechanism by which apoptosis induced via the tumor necrosis factor (TNF) receptor is prevented in infected epithelial...
متن کاملIAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis
James E. Vince,1 W. Wei-Lynn Wong,1,8 Nufail Khan,1,8 Rebecca Feltham,1,8 Diep Chau,1 Afsar U. Ahmed,1 Christopher A. Benetatos,2 Srinivas K. Chunduru,2 Stephen M. Condon,2 Mark McKinlay,2 Robert Brink,3 Martin Leverkus,4 Vinay Tergaonkar,5 Pascal Schneider,6 Bernard A. Callus,1 Frank Koentgen,7 David L. Vaux,1 and John Silke1,* 1Department of Biochemistry, La Trobe University, Kingsbury Drive,...
متن کاملDestabilizing Influences in Apoptosis Sowing the Seeds of IAP Destruction
Inhibitor of apoptosis proteins (IAPs) can block apoptosis through interactions with members of the caspase family of cysteine proteases. Recent developments suggest that ubiquitin-proteasome mediated destruction of the Drosophila IAP, DIAP1, is a key event during the initiation of programmed cell death in the fly.
متن کاملA Giant Ubiquitin-conjugating Enzyme Related to IAP Apoptosis Inhibitors
Ubiquitin-conjugating enzymes (UBC) catalyze the covalent attachment of ubiquitin to target proteins and are distinguished by the presence of a UBC domain required for catalysis. Previously identified members of this enzyme family are small proteins and function primarily in selective proteolysis pathways. Here we describe BRUCE (BIR repeat containing ubiquitin-conjugating enzyme), a giant (528...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.c400236200